Neomycin/polymyxin B/bacitracin, also known as triple antibiotic ointment, is an antibiotic medication used to reduce the risk of infections following minor skin injuries. It contains the three antibiotics neomycin, polymyxin B, and bacitracin. It is for topical use.

Possible side effects include itchiness and skin rash, and in rare cases hearing loss. It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria.

The combination was approved for medical use in the United States in 1971. It is available over the counter in the United States. In 2020, it was the 409th most commonly prescribed medication in the United States, with more than 100 thousand prescriptions.